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ГЕРОНТОЛОГИЯ
«GERONTOLOGY» Scientific Journal

БИОГЕРОНТОЛОГИЯ

BIOLOGICAL CHARACTERISTICS ACTIVATION VANILLOID AND PURINERGIC RECEPTOR UROTHELIA IN MEN OF DIFFERENT AGES

Pranovich A.A.1, Kvetnaja T.V.1, Selivanov A.N.2
1. Autonomous nonprofit scientific organization of higher education research centre Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg
2. Public health facilities «The City Clinical Hospital № 31», St. Petersburg
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Summary:
Currently, the issue of finding biological markers of pathological aging remains relevant. The aim of the study was to study the biological features of activation of vanilloid and purinergic urothelium receptors in men of different ages. Identified in the process of normal aging the level of activity vanilloid and purinergic receptor urothelia remains stable and persists regardless of the increasing age level of 56.7-63.5 per cent to vanilloid receptors and 55.4-63.4 per cent for purinergic receptors. With pathological aging of the urogenital tract, there is a significant increase in the activity of vanilloid purinergic urothelium receptors up to 146.5% in old age and up to 169.9% in old age. Thus, the activity indicates of vanilloid and purinergic receptors can serve as biological markers of pathological aging of the urogenital tract on the model of combination of hyperfunction of urothelium and systemic atherosclerosis. Identifying activity vanilloid and purinergic receptor urothelia as biological markers for the differentiation of physiological and pathological processes of ageing of the urogenital tract may serve as additional criteria for the formation of groups of patients to conduct activities for the prevention of premature aging.
Keywords premature aging, biological markers, pathological aging, urothelium, elderly age.

Bibliographic reference:
Pranovich A.A., Kvetnaja T.V., Selivanov A.N., BIOLOGICAL CHARACTERISTICS ACTIVATION VANILLOID AND PURINERGIC RECEPTOR UROTHELIA IN MEN OF DIFFERENT AGES // «GERONTOLOGY» Scientific Journal. - 2016. - №4;
URL: http://www.gerontology.su/magazines?textEn=267 (date of access: 06.12.2021).

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