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ГЕРОНТОЛОГИЯ
«GERONTOLOGY» Scientific Journal

БИОГЕРОНТОЛОГИЯ

PEPTIDES TISSUE-SPECIFICALLY STIMULATE THE EXPRESSION OF SIGNALING MOLECULES IN THE SPLEEN CELL CULTURES OF DIFFERENT AGE ANIMALS

Linkova N.S.1,2, Chervyakova N.A.1, Dudkov A.V.1, Kostylev A.V.1, Tendler S.M.3
1. Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia
2. Saint Petersburg Polytechnical University
3. Karolinska University Hospital, Solna, Stockholm, Sweden
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Summary:
In maintaining the functional activity of the immune system with the nervous and endocrine systems involved signaling molecules. Most signaling molecules are multifunctional regulatory peptides such as: neuropeptides VIP (vasoactive intestinal peptide) and CGRP (calcitonin gene related peptide), which are synthesized in the immune cells, and the expression level of which decreases with age. The purpose of research - a comparative study of the effects of peptide bioregulators (PB) on the expression of signaling molecules in cultures of spleen cells from animals of different ages. As a result of this work it was found that in organotypic cultures of young and old animals spleen was shown target action of peptide bioregulators (thymogen, dipeptide AB-0). Peptides AB-0 and timogen activate expression of macrophages (CD68) and B cells (CD20) markers in spleen of various age animals.
Keywords immune system, peptides, targeted action, cell cultures, ageing.

Bibliographic reference:
Linkova N.S., Chervyakova N.A., Dudkov A.V., Kostylev A.V., Tendler S.M., PEPTIDES TISSUE-SPECIFICALLY STIMULATE THE EXPRESSION OF SIGNALING MOLECULES IN THE SPLEEN CELL CULTURES OF DIFFERENT AGE ANIMALS // «GERONTOLOGY» Scientific Journal. - 2014. - №2;
URL: http://www.gerontology.su/magazines?textEn=164 (date of access: 21.11.2017).

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