Электронный научный журнал

The problem of treating complications of diabetes continues to be relevant in modern medicine. One of the complications of diabetes is the "diabetic foot" syndrome. In this complication, there is a complex of anatomical and functional changes that lead to the development of tissue ischemia (hypoxia), accompanied by increased trauma and infection of the soft tissues of the foot. It should be noted that such complications lead to early disability of patients, up to amputation of the foot and death. The aim of this work is to investigate the local application of the dipeptide bioregulator L-glutamic-L-tryptophanic acid (L-Glu-L-Trp) , aimed at activating soft tissue oxygenation by inhibiting the synthesis of HIF factor 1A, which is an urgent task of medicine and a pathogenetic approach to the treatment of complications of diabetes mellitus.