The authors present a review of the literature on the clinical and molecular features of malignant neoplasms with microsatellite instability (MSI) of different ages. MSI can be found in cancer patients of any age, as it occurs in response to disturbances in the Unpaired DNA Base Reparation System (DNA mismatch repair; MMR), which is present in the cells of our body throughout life. For all the malignancies described above, two mechanisms play a key role in the emergence of MSI: epigenetic inactivation and germinal mutations of the MMR genes. For the first mechanism, the risks increase significantly with the aging of the organism and are predominantly caused by hyper-methylation of the MLH1 promoter, while tumors associated with hereditary MMR disorders appear at an earlier stage of life. Also, it is worth noting that the female sex is an unfavorable prognostic factor for the development of malignant neoplasms with MSI at any age.
Hammad V.A., Hammad E.V., Poltorackij A.N., Fadeeva P.A., CLINICAL AND MOLECULAR PECULIARITIES OF MALIGNANT NEW-FORMATIONS WITH MICROSATELLITE INSTABILITY IN PATIENTS OF VARIOUS AGE (REVIEW OF LITERATURE) // «GERONTOLOGY» Scientific Journal. - 2018. - №1; URL: http://www.gerontology.su/magazines?textEn=275 (date of access: 19.04.2024).