This article discusses the medical and social age-associated syndromes as a possible object of preventive action. The authors identified the conditions (they were designated as medico-social syndromes) that determine the quality of people's lives and the degree of their independence in everyday life in old age, but the risk of their development is associated with adulthood, their rating-scaling. The average age of the appearance of the first signs of the studied medical and social syndromes, the average age of patients in whom these syndromes are registered in real practice under the existing system of care, the average age of patients in dispensary registration with signs of these conditions. While leading medico-social syndromes should be considered a cognitive deficit, sarcopenia, hypo mobility syndrome, malnutrition syndrome, and the vision loss syndrome and their primary and secondary prevention requires not only population-based, but personalized approach. The formation of leading medico-social syndromes and diseases that lead to it, starts about 15-18 years before they are recorded in real medical practice, which is a reserve of increase efficiency of preventive care by shifting the personalized preventive measures at earlier age groups.