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ГЕРОНТОЛОГИЯ
«GERONTOLOGY» Scientific Journal

БИОГЕРОНТОЛОГИЯ

CHANGES OF BIOLOGICAL MARKERS IN THE ORAL FLUID IN FRAILTY SYNDROME AND VIOLATIONS OF NUTRITIVE STATUS ON THE BACKGROUND OF POLYMORBIDITY

Matevosjan S.I.1, Burjagina N.V.2, Kvetnaja T.V.1, Gurko G. I.1
1. Autonomous nonprofit scientific organization of higher education research centre Saint Petersburg Institute of Bioregulation and Gerontology, St. Petersburg
2. Federal State Autonomous Educational Institution of Higher Education ”Belgorod State National Research University”, Belgorod
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Summary:
This article presents results of analysis changes in biological markers in the oral fluid in frailty syndrome and violations of nutritional status in the background polymorbidity. A correlation analysis was performed in patients with the frailty syndrome. The frailty syndrome had a statistically significant positive correlation with malnutrition syndrome (r=0,92; pdrome was one of the leading clinical and medico- social syndrome in the structure of geriatric syndromes, in particular, in the development of frailty syndrome. Determination activity of local immune molecules response, such as TNF-α, IL-1β and IL-6, as well as peroxidase activity, concentration lysozyme and lactoferrin in the oral fluid is informative and promising a marker for determining violations of geriatric status, namely, a predictor development of frailty syndrome and, in particular, malnutrition syndrome.
Keywords frailty, oral fluid, nutritional status, malnutrition syndrome, polymorbidity, geriatric syndromes, elderly people.

Bibliographic reference:
Matevosjan S.I., Burjagina N.V., Kvetnaja T.V., Gurko G. I., CHANGES OF BIOLOGICAL MARKERS IN THE ORAL FLUID IN FRAILTY SYNDROME AND VIOLATIONS OF NUTRITIVE STATUS ON THE BACKGROUND OF POLYMORBIDITY // «GERONTOLOGY» Scientific Journal. - 2017. - №3;
URL: http://www.gerontology.su/magazines?textEn=271 (date of access: 06.12.2021).

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