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«GERONTOLOGY» Scientific Journal

PECULIARITIES OF INDIVIDUAL INDICATORS OF CALCIUM HOMEOSTASIS IN SENILE PATIENTS WITH ISCHEMIC HEART DISEASE WITH AND ARTERIAL HYPERTENSION SYNDROME

Osmanova S.S.1
1. Medical Academy named after S.I. Georgievsky, Crimean Federal University named after V.I. Vernadsky
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Summary:
Calcium ions play an important regulatory role in many biological processes, such as muscle contraction, thrombus formation, neurotransmitter release, hormonal responses, exocytosis, tissue mineralization, division, adhesion and cell growth, cell apoptosis, etc. However, in the senil, there is a redistribution of various fractions of Ca2+ ions in the blood, which affects the course of the disease. 48 patients with ischemic heart disease (mean age of 76.6 years) were examined, 32 of whom had coronary artery disease in combination with coronary arteryatherosclerosis (mean age 78.5 years), 25 IHD with symptomatic hypertension (mean age 72.4 years), control group - 22 practically healthy people, comparable in age. The content of Ca2 + in the blood plasma among all groups was in the range of normal indices and did not differ significantly. In particular, an increase in the concentration of ionized Ca leads to its accumulation in cardiomyocytes, which increases the accumulation of LPO products, which are one of the main pathogenetic link sof IHD. Also, a correlation was found between the increase in the level of intracellular Ca and the severity of arterial hypertension in elderly people with IHD.
Keywords ischemic heart disease, senile age, calcium homeostasis.

Bibliographic reference:
Osmanova S.S., PECULIARITIES OF INDIVIDUAL INDICATORS OF CALCIUM HOMEOSTASIS IN SENILE PATIENTS WITH ISCHEMIC HEART DISEASE WITH AND ARTERIAL HYPERTENSION SYNDROME // «GERONTOLOGY» Scientific Journal. - 2017. - №4;
URL: http://www.gerontology.su/magazines?textEn=247 (date of access: 22.07.2018).

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