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«GERONTOLOGY» Scientific Journal

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QUANTITATIVE PREDICTION TOXICOLOGICAL EFFECTS OF ACTIVE PHARMACEUTICAL INGREDIENTS OF THE MODEL GERIATRIC DRUG FOR TREATMENT OF EARLY CATARACT

Bessarabov V.I.1, Palchevskaja T.A.1, Kuryshko G.G.1, Strokan A.P.1, Zubko V.A.1
1. Kyiv National University of Technologies and Design, Industrial Pharmacy Department, Kyiv, Ukraine
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Summary:
The article discusses the results of the study endotoxicity active pharmaceutical ingredients (API) of model geriatric drug for the treatment of cataract in the early stages. The study was conducted by using in silico virtual screening when predicting the spectrum of activity of substances (Prediction of Activity Spectra for Substances (PASS)). It is shown that the API adenosine and N-acetylcarnosine that could potentially form the basis of a model of geriatric drug in dosage form of eye drops for the treatment of cataract in the early stages, are of low toxicity by the results of QSAR analysis of the toxicological effects of chemicals on model organisms (rat) for the four types of administration (orally, intravenously, intraperitoneally, subcutaneously). It was concluded that a drug designed APIs meet the specific requirements geriatric drugs from a position of low endotoxicity.
Keywords in silico, virtual screening, elderly people, active pharmaceutical ingredients, gerontology.

Bibliographic reference:
Bessarabov V.I., Palchevskaja T.A., Kuryshko G.G., Strokan A.P., Zubko V.A., QUANTITATIVE PREDICTION TOXICOLOGICAL EFFECTS OF ACTIVE PHARMACEUTICAL INGREDIENTS OF THE MODEL GERIATRIC DRUG FOR TREATMENT OF EARLY CATARACT // «GERONTOLOGY» Scientific Journal. - 2014. - №4;
URL: http://www.gerontology.su/magazines?textEn=189 (date of access: 19.11.2017).

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