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ГЕРОНТОЛОГИЯ
«GERONTOLOGY» Scientific Journal

БИОГЕРОНТОЛОГИЯ

QUANTITATIVE CHANGES IN SUBPOPULATIONS OF T-CELLS WITH CHRONIC NONSPECIFIC INFLAMMATORY DISEASES IN CENTENARIANS

Toporova S.G.1, Miroshnichenko I.V.1, Stolpnikova V.N.1, Levashova T.V.1
1. Russian national research medical university N.I. Pirogov, Russian gerontological research center, Moscow, Russia
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Summary:
The purpose of the study was to establish an association between chronic and immune inflammation in centenarians and immune aging. By means of retrospective analysis of case histories of 98 centenarians and immunograms obtained by the polychromatic flow cytometry method ) it was shown that the majorly of patients had 2-3 HNVZ, increased number of activated CD3 + HLA-DR - T cells (Tact), CD4 + and CD8 + deficiency. According to the cluster analysis 2 groups of patients were formed which demonstrated the similar types of changes in the amount of CD4+/CD8T+ /Tact, which reflected the state of the T- cells immunity, its activation and deficiency. The associations between HNVZ regardless of their number and location, and varying degrees of deficiency in the amounts of CD4 + and / or CD8 + were determined. The associations between HNVZ and the development of immune inflammation we regard as a cause of the immune aging.
Keywords chronic inflammation, the activated T- cell, immunodeficit, cluster analysis, сcentenarians.

Bibliographic reference:
Toporova S.G., Miroshnichenko I.V., Stolpnikova V.N., Levashova T.V., QUANTITATIVE CHANGES IN SUBPOPULATIONS OF T-CELLS WITH CHRONIC NONSPECIFIC INFLAMMATORY DISEASES IN CENTENARIANS // «GERONTOLOGY» Scientific Journal. - 2014. - №2;
URL: http://www.gerontology.su/magazines?textEn=165 (date of access: 19.11.2017).

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