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«GERONTOLOGY» Scientific Journal

SUBFAMILY OF FGF19, FGF21, FGF23 FIBROBLASTS GROWTH FACTORS AS FACTORS OF "JUVENILITY". EPIGENETIC REGULATION MECHANISMS

Khavinson V.Kh.1,2, Kuznik B.I.3,4, Linkova N.S.1,5, Sall T.S.1, Orlova O.A.1
1. Saint-Petersburg Institute of Bioregulation and Gerontology, St. Petersburg
2. Pavlov Institute of Physiology of RAS, St.-Petersburg
3. Chita State Medical Academy, Chita
4. Innovation Clinic “Health Academy”, Chita
5. Peter the Great Saint Petersburg Polytechnic University, St. Petersburg
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Summary:
This article provides information about FGF19, FGF21, FGF23 fibroblasts grow factors implication in development of age-related pathologies, where these fibroblasts grow factors have the properties of endogenous hormones. FGF19 plays an important role in development of diabetes mellitus type 2, atherosclerotic cardiovascular disease, chronic liver diseases. FGF21 is a neuroprotective protein, it regulates lipid and glucose metabolism. FGF23 is a marker for cell senescence and can regulate intracellular calcium metabolism. Decreasing of FGF23 gene expression is correlated with osteoporosis progression. The hypothesis about KE, KED, AEDG peptides regulation of FGF19, FGF21, FGF23 genes expression is under discussion. It was shown that these peptides stimulate fibroblast division and have various geroprotective effects.
Keywords fibroblasts grow factors, short peptides, aging, pathology.

Bibliographic reference:
Khavinson V.Kh., Kuznik B.I., Linkova N.S., Sall T.S., Orlova O.A., SUBFAMILY OF FGF19, FGF21, FGF23 FIBROBLASTS GROWTH FACTORS AS FACTORS OF "JUVENILITY". EPIGENETIC REGULATION MECHANISMS // «GERONTOLOGY» Scientific Journal. - 2017. - №1;
URL: http://www.gerontology.su/magazines?textEn=219 (date of access: 21.11.2017).

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